Increased levels of Oxidative Stress often results in damage to cellular components which we now know can also be a precursor to tissue specific or systemic disease states.
Determining the role of Oxidative Stress in the etiology and treatment of disease has become a common theme for medical researchers investigating pathophysiological processes involved in biological decline due to disease and aging.
Some common medical conditions wherein Oxidative Stress is thought to play a role are:
- Heart Attack (Myocardial Infarct)
- Hemolytic Anemia
- Multiple Sclerosis
- Organ Transplantation
- Parkinson’sRheumatoid Arthritis
- Sickle Cell Anemia
Effects of combination therapy with vildagliptin and valsartan in a mouse model of type 2 diabetes
This study used a mouse model of type 2 diabetes to investigate the effects of combining different types of therapies on glucose tolerance, insulin secretion as well as biomarkers of inflammation and oxidative stress. Liver tissue was tested for nitrotyrosine using product NWK-NTR01. Significant lowering of liver nitrotyrosine levels in the treatment group compared to controls was reported as evidence that combination therapy is effective in mitigating oxidative stress.
Katsutoshi Miyagawa et al, Cardiovascular Diabetology, 12 (1), p.160, Nov 2013 (PDF)
Peroxiredoxin 1 Controls Prostate Cancer Growth through Toll-Like Receptor 4–Dependent Regulation of Tumor Vasculature
This study looked at the role of Peroxiredoxin 1 (PRX1) in regulating prostate tumor growth. The authors used product NWK-PRX01 to measure levels of PRX1 in various cell lines. The results showed that PRX1 is overexpressed in human prostate cancer and that inhibition of PRX1 reduced tumor vascular formation and function. Taken together the results suggest that PRX01 could be a potential target for prostate cancer treatment.
Jonah R. Riddell et al, Cancer Res March 1, 2011 71; 1637 (new window)
Relationship among Oxidative Stress, DNA Damage, and Proliferative Capacity in Human Corneal Endothelium
This study investigated whether the DNA of human corneal endothelial cells (HCECs) is susceptible to oxidative damage and if yes whether this might affect the proliferative capacity of HCECs. The authors used product NWK-8OHDG02 to show that levels of 8OHDG were significantly higher for DNA isolated from older corneas.
Nancy C. Joyce et al, Invest. Ophthalmol. Vis. Sci. May 2009, vol. 50 no. 5 2116-2122 (new window)