Ameliorative Effects of Resveratrol on Oxidative Stress Biomarkers in Horses
Mary Ucheagha Ememe, Wayuta Philip Mshelia, Joseph Olusegun Ayo
Journal of Equine Veterinary Science,  (June 2015) : Volume 35 Issue 6, Pages 518-523
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  • Aging and lameness increased oxidative damage in horses.
  • Equithrive joint reduced concentration of malondialdehyde in lame and aged horses.
  • Equithrive joint raised activities of superoxide dismutase and catalase in the horses.
  • Glutathione peroxidase activity decreased in horses treated with equithrive joint.
  • Abstract  The aim of the present study was to evaluate the influence of age and lameness on antioxidant status in horses administered resveratrol supplement (Equithrive Joint). A total of 16 horses of both sexes, aged between 15 and 22 years, showing lameness score of 3 and weighing 350–450 kg were used, comprising eight horses which were administered resveratrol supplement for 4 weeks and eight others which served as control and given only Saccharomyces cerevisiae yeast strain used as carrier in the supplement. Blood samples were collected from each horse before supplementation (week 0) and at first, second, third, and fourth weeks of the experiment. Serum antioxidant marker of malondialdehyde (MDA) concentration, superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities were determined by standard methods. Resveratrol supplement administration reduced significantly (P <.05) the concentration of MDA and activity of GPx but increased that of SOD and catalase. The result showed that aging and lameness increased oxidative damage in horses, and resveratrol supplement exerted some protective effects on the aged and lame horses by increasing the antioxidant capacity of the animals


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